Interaction of Melanin with Metal Ions Modulates Their Cytotoxic Potential

Abstract Melanin is one the most common biological pigments. In humans, specialized cells called melanocytes synthesize pigment from tyrosine and 3,4-dihydroxyphenylalanine via enzyme-catalyzed reactions spontaneous processes. The formed melanin granule consists of nanoaggregates oligomers containing different monomers. Although main function protection against damage solar radiation, may also be involved in oxidative stress. latter function, sequestration redox-active metal ions scavenging reactive oxygen species are importance. paper reviews basic physicochemical properties responsible for binding discusses specific conditions that induce cytotoxicity such as iron copper by facilitating their redox activation release melanin. While value EPR spectroscopy other EPR-related techniques study emphasized, concomitant use methods efficient approach.